George Clooney, Julianna Margulies, Noah Wylie, Anthony Edwards and Gloria Reuben are among the ER cast members set to reunite for a special edition of Star in the House.

They’re getting together for a special Earth Day episode of the streaming show, which will take place on 22nd April.

Other ER cast members joining the show include Alex Kingston, Goran Visnjic, Paul McCrane, Ming-Na Wen, Laura Cerón, Yvette Freeman, and Conni Marie Brazelton.

The virtual reunion will raise funds for the Waterkeeper Alliance, an organisation aimed at protecting clean water globally.

Reuben, who serves as president of Waterkeeper Alliance, said, “I am absolutely thrilled to be reuniting with my ER family for a cause that is so close to my heart, and so grateful to Seth and James for allowing us to use their incredible platform to do so.”

The show will be available to watch on the Stars in the House YouTube channel, as well as starsinthehouse.com